[Malignant otitis externa and diabetes: report of 4 cases]

A Lecube Torelló1, C Hernández Pascual, J Lorente Guerrero

  • 1Sección de Endocrinología, Hospital General Universitario Vall d'Hebron, Barcelona.

Revista Clinica Espanola
|February 25, 2000
PubMed

Insights

Malignant otitis externa (MOE), a severe Pseudomonas aeruginosa infection, primarily affects elderly diabetics. Suspect MOE in diabetic patients with persistent otitis, as it can cause cranial nerve issues and bony destruction.

Area of Science:

  • Otolaryngology
  • Infectious Diseases
  • Diabetology

Background:

  • Malignant otitis externa (MOE) is a rare, aggressive infection.
  • Pseudomonas aeruginosa is the primary causative agent.
  • MOE predominantly affects elderly patients with diabetes mellitus.

Observation:

  • Four cases of MOE were diagnosed over seven years.
  • Clinical signs included severe ear pain, discharge, cranial nerve palsies, and bone destruction.
  • Outcomes varied, with one fatality due to bronchoaspiration and two patients experiencing sequelae.

Findings:

  • MOE requires high clinical suspicion in diabetic patients with refractory otitis.
  • Facial palsy in diabetics may indicate MOE, not solely diabetic mononeuropathy.
  • Early diagnosis and intervention are critical for improved outcomes.

Implications:

  • Clinicians should consider MOE in diabetic patients with persistent ear infections.
  • Facial nerve involvement warrants investigation for MOE, especially with coexisting otitis.
  • Prompt recognition and management of MOE can prevent severe complications and mortality.

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Diabetes Mellitus: Introduction01:26

Diabetes Mellitus: Introduction

Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...