Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Osteocyte function, osteocyte death and bone fracture resistance.

B S Noble1, J Reeve

  • 1University Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.

Molecular and Cellular Endocrinology
|February 25, 2000
PubMed
Summary

Osteocytes, the most abundant bone cells, regulate bone remodeling in response to mechanical stress. They utilize familiar signaling pathways and receptors to maintain bone strength and adapt to the body's needs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A prospective, multi-site, observational study assessing the treatment thresholds of new onset atrial fibrillation in the critically ill.

Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine·2026
Same author

Exploring health and social care preferences for people with dementia and mild cognitive impairment: a systematic review of discrete choice experiments.

Aging & mental health·2025
Same author

Examining the knowledge work of person-centred care: Towards epistemic reciprocity.

Patient education and counseling·2022
Same author

Effects of preoperative physiotherapy on signs and symptoms of pulmonary collapse and infection after major abdominal surgery: secondary analysis of the LIPPSMAck-POP multicentre randomised controlled trial.

Perioperative medicine (London, England)·2021
Same author

Cognitive profile of young children with Williams syndrome.

Journal of intellectual disability research : JIDR·2021
Same author

Green Foxtail (Setaria viridis), A Naturally Infected Grass Host of Iris yellow spot virus in Utah.

Plant disease·2019

Area of Science:

  • Bone Biology
  • Cellular Signaling
  • Skeletal Physiology

Background:

  • Osteocytes are the most numerous cells within bone tissue.
  • Their precise function has been historically debated but is now increasingly understood.
  • They play a crucial role in bone's adaptation to mechanical stimuli.

Purpose of the Study:

  • To elucidate the signaling mechanisms and functions of osteocytes.
  • To understand how osteocytes contribute to bone adaptation and homeostasis.
  • To explore the molecular pathways involved in osteocyte-mediated bone remodeling.

Main Methods:

  • Analysis of molecular signaling pathways (nitric oxide, prostaglandins).
  • Investigation of cell-cell communication via gap junctions.

Related Experiment Videos

  • Examination of receptors for hormones (parathyroid hormone, estrogen) and neurotransmitter-related molecules.
  • Study of osteocyte apoptosis and secretion of proteins like osteopontin.

    • Main Results:

    • Osteocytes modulate signals from mechanical loading, directing bone tissue formation and resorption.
    • They employ signaling pathways common to other tissues.
    • Osteocytes possess receptors for key hormones and express molecules involved in neurotransmission, influencing their own function.

    Conclusions:

    • Osteocytes are central regulators of bone adaptation, growth, and maintenance.
    • Their signaling capabilities allow bone to efficiently meet mechanical demands.
    • Osteocyte function is influenced by hormonal and mechanical cues, as well as intrinsic cellular processes like apoptosis.