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Updated: Oct 17, 2026

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array (HMCA)-based Plates
Published on: October 25, 2018
Non-linear model of cancer growth and metastasis: a limiting nutrient as a major determinant of tumor shape and
G P Pescarmona1, M Scalerandi, P P Delsanto
1Dipartimento di Genetica, Biologia e Chimica Medica, Universita di Torino, Turin, Italy.
Abstract:
A new approach for modelling the spatio-temporal evolution of tumors is presented. To test its validity, a very basic model is considered, which, in spite of its simplicity, is capable of generating a multiplicity of morphologies and growth and migration rates. From an in-vivo scenario of basic life processes, cancer cell proliferation is described as a competition for basic nutrients. The chosen mathematical treatment and simulation techniques permit a direct implementation of the local nonlinear couplings existing between the various cell populations and the free and bound nutrient concentration. A discussion of the results and proposed improvements and applications of the model is also presented.
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