Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fibroblast growth factor-2.

M A Nugent1, R V Iozzo

  • 1Department of Biochemistry, Boston University School of Medicine, MA 02118, USA. nugent@biochem.bumc.bu.edu

The International Journal of Biochemistry & Cell Biology
|February 25, 2000
PubMed
Summary

Fibroblast growth factor-2 (FGF-2) impacts cell function and blood vessel growth, potentially contributing to diseases like cancer. Manipulating FGF-2

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differentiated activities of decorin and biglycan in the progression of post-traumatic osteoarthritis.

Osteoarthritis and cartilage·2021
Same author

Achilles tendons from decorin- and biglycan-null mouse models have inferior mechanical and structural properties predicted by an image-based empirical damage model.

Journal of biomechanics·2015
Same author

The systemic delivery of an oncolytic adenovirus expressing decorin inhibits bone metastasis in a mouse model of human prostate cancer.

Gene therapy·2014
Same author

Heparan sulfate-protein binding specificity.

Biochemistry. Biokhimiia·2013
Same author

Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2010
Same author

Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling.

Oncogene·2009

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Fibroblast growth factor-2 (FGF-2) is a heparin-binding protein influencing diverse cell functions.
  • FGF-2 plays a role in angiogenesis, crucial for diseases, wound healing, and tissue development.
  • FGF-2 structure involves beta-sheets and basic residues, interacting with cell surface receptors.

Purpose of the Study:

  • To explore the multifaceted roles of FGF-2 in cellular processes.
  • To investigate the mechanisms underlying FGF-2's biological activities, including receptor interactions and intracellular functions.
  • To examine the influence of heparan sulfate proteoglycans on FGF-2 activity.

Main Methods:

  • Review of existing literature on FGF-2 structure, function, and interactions.
  • Analysis of FGF-2's role in angiogenesis and disease pathogenesis.
  • Investigation of FGF-2's intracellular and nuclear functions.
  • Examination of heparan sulfate proteoglycan modulation of FGF-2.

Main Results:

  • FGF-2 stimulates angiogenesis, implicated in cancer and atherosclerosis.
  • FGF-2's activity is mediated by cell surface receptors, tyrosine kinase activity, and signaling pathways like MAP kinases.
  • Intracellular and nuclear roles of FGF-2 are increasingly recognized.
  • Heparan sulfate proteoglycans can both enhance and inhibit FGF-2 activity.

Conclusions:

  • FGF-2 is a key regulator of angiogenesis and cellular processes with implications in disease.
  • Understanding FGF-2's receptor binding and intracellular actions is vital.
  • Modulating heparan sulfate interactions with FGF-2 offers potential for clinical applications.

Related Experiment Videos