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Iodinated free fatty acid and 201T1 uptake in chronically hypoperfused myocardium: histologic correlation study
T Kudoh1, E Tadamura, N Tamaki
1Department of Nuclear Medicine and Diagnostic Imaging, School of Medicine, Kyoto University, Japan.
Unlabelled:
123I-15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) is a tracer for the evaluation of ischemic heart disease. The purpose of this study was to assess the relationship between 1231-BMIPP uptake and myocardial fibrosis.
Methods:
Fifteen patients who underwent cardiac surgery were examined by imaging with 201TI and 123I-BMIPP, and histologic specimens were taken during surgery. The relative uptake of 201TI (%TI) and that of 123I-BMIPP (%BMIPP) were calculated. The percentage of fibrosis (%fibrosis) was analyzed with the specimen.
Results:
%TI correlated strongly with %fibrosis (r = -0.94; P < 0.001). %BMIPP also correlated significantly with %fibrosis (r = -0.88; P < 0.001), but the change in %BMIPP looked biphasic. In the category of only mild fibrosis, %BMIPP showed a steep decrease. 123I-BMIPP-201TI mismatch was found only for fibrosis <20%.
Conclusion:
123I-BMIPP gave specific information about metabolic changes that occurred in ischemic myocardium without severe fibrotic changes.