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Disposition of dodecanedioic acid in humans
A Bertuzzi1, G Mingrone, A Gandolfi
1Istituto di Analisi dei Sistemi ed Informatica del CNR, Università di Roma "La Sapienza", Rome, Italy. bertuzzi@iasi.rm.cnr.it
The Journal of Pharmacology and Experimental Therapeutics
|February 25, 2000
Summary
Dodecanedioic acid (C12) shows efficient tissue uptake and oxidation in humans, with low urinary excretion. This suggests potential for C12 as an energy source in parenteral nutrition.
Area of Science:
- Metabolism and Nutrition
- Pharmacokinetics
- Biochemistry
Background:
- Parenteral nutrition requires efficient energy substrates.
- Dodecanedioic acid (C12) is a medium-chain fatty acid with potential nutritional applications.
Purpose of the Study:
- To investigate the disposition and metabolic fate of dodecanedioic acid (C12) in healthy volunteers.
- To evaluate the potential of C12 as an energy source for parenteral nutrition.
Main Methods:
- Intravenous infusion of radiolabeled C12 in six healthy male volunteers.
- Measurement of serum C12 concentrations, urinary excretion, and expired CO2.
- Kinetic modeling (single compartment, saturable and linear uptake models) to describe C12 disposition.
Main Results:
- Urinary excretion of C12 was low (around 5%).
- C12 oxidation was high, with 81.7% of the administered dose recovered as CO2.
- Kinetic models predicted significant calorie delivery, with maximal rates up to 750 kcal/day.
Conclusions:
- Dodecanedioic acid (C12) is efficiently metabolized and oxidized in humans.
- Low urinary excretion and high oxidation rates support the potential use of C12 in parenteral nutrition.
- Further research into C12 utilization for nutritional support is warranted.