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Hormonal carcinogenesis.

B E Henderson1, H S Feigelson

  • 1Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, MS44, PO Box 33800, Los Angeles, CA 90033-0800, USA. behenderson@hsc.usc.edu

Carcinogenesis
|February 26, 2000
PubMed
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Hormone-related cancers share a common mechanism driven by hormones. This study develops polygenic models for breast and prostate cancer risk, identifying key genes involved in hormone metabolism and transport for early detection and prevention strategies.

Area of Science:

  • Oncology
  • Genetics
  • Endocrinology

Background:

  • Hormone-related cancers (breast, prostate, etc.) share a carcinogenesis mechanism involving hormone-driven cell proliferation and genetic errors.
  • Specific genes driving hormone-related cancer progression remain largely unknown.
  • Current understanding necessitates novel strategies for early detection and prevention.

Purpose of the Study:

  • To review the epidemiology of endometrial and breast cancer to illustrate hormonal carcinogenesis paradigms.
  • To discuss new strategies for early detection and prevention of hormonal carcinogenesis.
  • To develop and validate polygenic models for breast and prostate cancer predisposition.

Main Methods:

  • Utilized epidemiological data for endometrial and breast cancer to illustrate hormonal carcinogenesis.

Related Experiment Videos

  • Developed polygenic models for breast and prostate cancer risk assessment.
  • Included genes involved in steroid hormone metabolism and transport (e.g., HSD17B1, CYP17, CYP19, ER, AR, SRD5A2, HSD3B2).
  • Analyzed gene variants and their interaction with known hormonal risk factors.

    • Main Results:

    • Established polygenic models for breast and prostate cancer risk.
    • Demonstrated that combinations of genes with minor variations can cumulatively define high-risk profiles.
    • Presented data from a multi-ethnic cohort supporting the developed models.

    Conclusions:

    • Polygenic models integrating genes in steroid hormone pathways offer a clinically useful approach to identify cancer predisposition.
    • These models, combined with known risk factors, can stratify individuals for targeted early detection and prevention of hormone-related cancers.
    • Further development of safe chemopreventives targeting specific gene sequences is warranted.