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Related Experiment Videos

Genome changes and gene expression in human solid tumors.

J W Gray1, C Collins

  • 1UCSF Cancer Center, 2340 Sutter Street, University of California San Francisco, San Francisco, CA 94143-0808, USA. jgray@cc.ucsf.edu

Carcinogenesis
|February 26, 2000
PubMed
Summary
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Large-scale genomic and gene expression analysis techniques are crucial for identifying genome aberrations and differentially expressed genes in human tumors. This review details methods for gene discovery and summarizes findings from solid tumor analyses.

Area of Science:

  • Genomics
  • Cancer Biology
  • Molecular Oncology

Background:

  • Advancements in genome-wide analysis techniques are crucial for understanding human tumors.
  • High-resolution localization of genome aberrations and detection of differentially expressed genes are key research areas.

Purpose of the Study:

  • To review commonly used large-scale genome and gene expression analysis techniques.
  • To outline genomic approaches for gene discovery.
  • To summarize findings from large-scale analyses of human solid tumors.

Main Methods:

  • Chromosome painting
  • Comparative genomic hybridization (CGH)
  • Representational difference analysis (RDA)
  • Restriction landmark genome scanning (RLGS)

Related Experiment Videos

  • Loss of heterozygosity (LOH) analysis
  • Differential display
  • Nucleic acid subtraction
  • Serial analysis of gene expression (SAGE)
  • Expression microarray analysis

    • Main Results:

    • These techniques enable high-resolution genome aberration localization in human tumors.
    • Methods for detecting differentially expressed genes are complementary to genomic analyses.
    • The Human Genome Program has provided essential resources like physical maps and sequencing data.

    Conclusions:

    • Large-scale genomic and gene expression analyses are accelerating cancer research.
    • These approaches facilitate gene discovery and understanding of solid tumor biology.
    • Continued advancements in these techniques are vital for cancer diagnostics and therapeutics.