Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA methylation: past, present and future directions.

K D Robertson1, P A Jones

  • 1University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, MS 83, Los Angeles, CA 90033, USA.

Carcinogenesis
|February 26, 2000
PubMed
Summary

DNA methylation, a key epigenetic mechanism, regulates gene expression and genome stability. Aberrant DNA methylation patterns are hallmarks of cancer, highlighting its critical role in development and disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive Lifestyle Improvement Program for Prostate Cancer (CLIPP) is associated with improvement in weight and components of metabolic syndrome in men exposed to androgen deprivation therapy for prostate cancer.

Prostate cancer and prostatic diseases·2021
Same author

DNA methylation in blood from neonatal screening cards and the association with BMI and insulin sensitivity in early childhood.

International journal of obesity (2005)·2017
Same author

Number and type of TET2 mutations in chronic myelomonocytic leukemia and their clinical relevance.

Blood cancer journal·2016
Same author

Pharmacokinetics and toxicity of the novel oral demethylating agent zebularine in laboratory and tumor bearing dogs.

Veterinary and comparative oncology·2015
Same author

NMDA receptor binding in focal epilepsies.

Journal of neurology, neurosurgery, and psychiatry·2015
Same author

Pulsed-coil magnet systems for applying uniform 10-30 T fields to centimeter-scale targets on Sandia's Z facility.

The Review of scientific instruments·2015

Area of Science:

  • Epigenetics and Genomics
  • Molecular Biology

Background:

  • DNA methylation involves adding a methyl group to cytosine in CpG dinucleotides, significantly impacting the mammalian genome.
  • It plays crucial roles in transcriptional repression, X chromosome inactivation, imprinting, and suppressing parasitic DNA.
  • While essential for embryonic development, DNA methylation patterns are often disrupted in cancer, exhibiting global hypomethylation and regional hypermethylation.

Purpose of the Study:

  • To review major findings in the DNA methylation field over the past two decades.
  • To summarize key future research directions in DNA methylation.
  • To highlight the role of DNA methylation in genome stability and DNA repair.

Main Methods:

  • Literature review of significant advancements in DNA methylation research.

Related Experiment Videos

  • Analysis of the impact of DNA methylation on gene expression and cellular processes.
  • Discussion of the implications of altered DNA methylation in disease, particularly cancer.

    • Main Results:

    • DNA methylation influences gene silencing through transcription factor inhibition and recruitment of methyl-binding proteins.
    • Disrupted methylation patterns, specifically hypermethylation of tumor suppressor gene promoters, contribute to cancer development.
    • Recent discoveries underscore DNA methylation's importance in DNA repair and genome stability.

    Conclusions:

    • DNA methylation is a fundamental epigenetic mechanism with broad genomic functions.
    • Aberrant DNA methylation is a critical factor in tumorigenesis.
    • The field of DNA methylation is rapidly evolving with exciting future research avenues.