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Costimulatory mechanisms in the elderly.

R B Effros1

  • 1Department of Pathology and Laboratory Medicine, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095-1732, USA. reffros@mednet.ucla.edu

Vaccine
|February 26, 2000
PubMed
Summary

Aging increases CD28- T cells, which cannot expand. This study shows repeated T cell division causes CD28 loss, potentially explaining age-related infections and cancer.

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Area of Science:

  • Immunology
  • Cell Biology
  • Gerontology

Background:

  • Aging is linked to more T cells lacking the CD28 molecule.
  • CD28 signaling is crucial for T cell proliferation.

Purpose of the Study:

  • Investigate if CD28- T cells are a distinct lineage or derived from CD28+ cells.
  • Understand the mechanism behind CD28 loss in T cells.

Main Methods:

  • Longitudinal cell culture analysis of T cell populations.
  • Tracking T cell division and CD28 expression over time.

Main Results:

  • Repeated T cell division leads to cell cycle arrest.
  • T cell division results in shortened telomeres and loss of CD28 expression.
  • Demonstrated that CD28- T cells arise from CD28+ T cells after repeated divisions.

Conclusions:

  • CD28- T cells are not a separate lineage but result from extensive T cell division.
  • This process may contribute to increased infection and cancer risk in the elderly.

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