Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circadian rhythms: new functions for old clock genes.

P L Lakin-Thomas1

  • 1Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge UK. pl106@mole.bio.cam.ac.uk

Trends in Genetics : TIG
|February 26, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Neurospora circadian clock: simple or complex?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2001
Same author

Rhythms of differentiation and diacylglycerol in Neurospora.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2001
Same author

sn-1,2-diacylglycerol levels in the fungus Neurospora crassa display circadian rhythmicity.

The Journal of biological chemistry·2000
Same author

Commentary: molecular and cellular models of circadian systems.

Journal of biological rhythms·2000
Same author

Circadian rhythms in Neurospora crassa: lipid deficiencies restore robust rhythmicity to null frequency and white-collar mutants.

Proceedings of the National Academy of Sciences of the United States of America·2000
Same author

Choline depletion, frq mutations, and temperature compensation of the circadian rhythm in Neurospora crassa.

Journal of biological rhythms·1998

Circadian clock research may be limited by current models. Re-evaluating the function of clock genes could reveal new insights into daily rhythms and uncover previously undiscovered clock genes.

Area of Science:

  • Chronobiology
  • Molecular Biology
  • Genetics

Background:

  • Circadian clocks regulate daily biological events.
  • Clock genes are key to understanding these rhythms.
  • A transcription-translation feedback-loop model is widely accepted for core clock mechanisms across species.

Purpose of the Study:

  • To investigate the limitations of the current transcription-translation feedback-loop model for circadian clocks.
  • To propose a re-evaluation of clock gene functions.
  • To identify potential new clock genes missed by existing assumptions.

Main Methods:

  • Characterization of 'clock genes' involved in daily rhythms.
  • Analysis of the transcription-translation feedback-loop model.
  • Exploration of potential biases in mutant screening due to a priori assumptions.

Related Experiment Videos

Main Results:

  • The established transcription-translation feedback-loop model may not fully explain circadian clock mechanisms.
  • Existing assumptions about circadian clocks might hinder the discovery of novel clock genes.
  • A different perspective on clock gene function is warranted.

Conclusions:

  • Current models of circadian clocks may be incomplete.
  • Further research should explore alternative functions of clock genes.
  • Overcoming preconceived notions is crucial for advancing the field of chronobiology.