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Selective serotonin reuptake inhibitors: implications for advanced nursing practice
1Elmira College, NY, USA.
Journal of the American Academy of Nurse Practitioners
|February 26, 2000
Summary
Selective serotonin reuptake inhibitors (SSRIs) are effective for depression. Reviewing SSRI data on side effects, interactions, and patient-specific factors is crucial for safe and effective prescribing.
Area of Science:
- Pharmacology
- Psychiatry
Background:
- Selective serotonin reuptake inhibitors (SSRIs) are a cornerstone in depression treatment.
- Understanding their profile relative to other antidepressants is essential for clinical practice.
Purpose of the Study:
- To review the comparative efficacy and characteristics of SSRIs.
- To highlight key considerations for prescribing SSRIs.
Main Methods:
- Literature review of SSRI efficacy, pharmacokinetics, side effects, and drug interactions.
- Analysis of dosing, cost, and special population considerations.
Main Results:
- SSRIs demonstrate well-documented efficacy in depression treatment.
- Key differences and similarities exist among SSRIs regarding half-life, side effects, interactions, dosing, and cost.
Conclusions:
- Comprehensive review of SSRI data is necessary before prescribing.
- Caution is advised when prescribing SSRIs to specific patient groups, including those on MAO inhibitors, the elderly, pregnant patients, and those on type 1C antiarrhythmia agents.