Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microelectrode-guided thalamotomy for Parkinson's disease.

M N Linhares1, R R Tasker

  • 1Department of Surgery, Toronto Western Hospital, University of Toronto, Ontario, Canada.

Neurosurgery
|February 26, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system.

Translational psychiatry·2016
Same author

Prevalence of headache in patients with Parkinson's disease and its association with the side of motor symptom onset.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2013
Same author

Rarae Aves.

Canadian Medical Association journal·2010
Same author

Neurons with spontaneous high-frequency discharges in the central nervous system and chronic pain.

Acta neurochirurgica. Supplement·2003
Same author

Kinaesthetic neurons in thalamus of humans with and without tremor.

Experimental brain research·2003
Same author

History of lesioning for pain.

Stereotactic and functional neurosurgery·2002

Microelectrode-guided thalamotomy effectively reduces parkinsonian tremor, with significant symptom improvement in most patients. This procedure shows promise for fewer complications and a potential learning curve for optimal results.

Area of Science:

  • Neurosurgery
  • Neurology
  • Medical Devices

Background:

  • Parkinsonian tremor significantly impacts patient quality of life.
  • Conventional treatments for parkinsonian tremor have limitations and potential complications.

Purpose of the Study:

  • To evaluate the outcomes of microelectrode-guided thalamotomy for parkinsonian tremor.
  • To assess the safety and efficacy of this technique in a cohort of 40 patients.

Main Methods:

  • Retrospective analysis of 40 microelectrode-guided thalamotomies (24 left, 16 right) performed between 1984-1996.
  • Evaluation by a blinded observer using semiquantitative scoring correlated with microelectrode recordings and lesion characteristics.
  • Comparison of outcomes between the first 20 and second 20 procedures to identify learning curve effects.

Related Experiment Videos

Main Results:

  • Significant tremor reduction in 75% of upper limbs and 73% of lower limbs at mean 35.8-month follow-up.
  • Improved success rates in the second 20 procedures (65% complete tremor abolition) compared to the first 20 (40%).
  • No significant persistent complications; learning curve suggested by improved outcomes and technical success with experience.

Conclusions:

  • Microelectrode-guided thalamotomy is an effective treatment for parkinsonian tremor.
  • The procedure may offer fewer complications than traditional methods.
  • A learning curve is apparent, with improved results over time and experience.