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Related Experiment Videos

Is leptin associated with hypertensive retinopathy?

G Uckaya1, M Ozata, A Sonmez

  • 1Department of Endocrinology and Metabolism, Gulhane School of Medicine, Etlik-Ankara, Turkey.

The Journal of Clinical Endocrinology and Metabolism
|February 26, 2000
PubMed
Summary
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Elevated plasma leptin levels are linked to higher grades of hypertensive retinopathy, even after accounting for body mass index. A critical leptin concentration threshold may be necessary for retinopathy development in hypertension.

Area of Science:

  • Cardiovascular Research
  • Endocrinology
  • Ophthalmology

Background:

  • Elevated plasma leptin is associated with essential hypertension.
  • Leptin promotes angiogenesis, and its receptor is present on vascular endothelium.
  • This suggests leptin may contribute to end-organ damage in hypertension.

Purpose of the Study:

  • To investigate the relationship between plasma leptin concentrations and hypertensive retinopathy (HR).

Main Methods:

  • 111 newly diagnosed essential hypertension patients and 79 normotensive controls were enrolled.
  • Ophthalmoscopy was used to assess retinopathy grade (Keith-Wagener classification).
  • Plasma leptin levels were measured and correlated with hypertension and retinopathy status.

Related Experiment Videos

Main Results:

  • Plasma leptin was significantly higher in hypertensive patients than controls.
  • Leptin levels increased progressively with higher grades of hypertensive retinopathy, even after BMI correction.
  • A plasma leptin threshold of 10.2 ng/mL was identified for the presence of retinopathy.

Conclusions:

  • Plasma leptin concentrations correlate with the severity of hypertensive retinopathy.
  • A critical leptin level appears necessary for retinopathy development in hypertension.
  • While potentially an epiphenomenon, a pathogenic role for leptin in hypertensive retinopathy cannot be ruled out.