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Related Experiment Videos

Molecular basis off hurthle cell papillary thyroid carcinoma.

C C Cheung1, S Ezzat, L Ramyar

  • 1Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Ontario, Canada.

The Journal of Clinical Endocrinology and Metabolism
|February 26, 2000
PubMed
Summary
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A subset of Hurthle cell tumors (HCTs) show features of papillary thyroid carcinoma (PTC) due to specific gene rearrangements. This finding supports classifying HCTs into adenomas, carcinomas, and PTC.

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Hurthle cell tumors (HCTs) are a distinct category of thyroid neoplasms.
  • Hurthle cell adenomas are benign, while Hurthle cell carcinomas are aggressive with poor prognosis.
  • Recent identification of Hurthle cell papillary thyroid carcinomas (PTCs) suggests underlying molecular events.

Purpose of the Study:

  • To investigate if a subset of HCTs represent PTC with specific molecular alterations.
  • To examine HCTs for ret/PTC gene rearrangements, which are unique to PTC.
  • To correlate molecular findings with clinical and histological features.

Main Methods:

  • Studied 50 HCTs for ret/PTC gene rearrangements.
  • Assessed papillary differentiation via light microscopy of nuclear features.

Related Experiment Videos

  • Utilized RT-PCR for ret/PTC gene transcripts and immunohistochemistry for ret protein expression.

    • Main Results:

    • Among 24 noninvasive tumors, 13 had ret/PTC transcripts, with 9 showing ret positivity.
    • Among 19 Hurthle cell carcinomas, 15 exhibited papillary features, ret/PTC transcripts, and ret positivity.
    • Tumors with ret/PTC rearrangements were more prone to lymph node metastasis than hematogenous spread.

    Conclusions:

    • A subset of HCTs display PTC features linked to specific ret/PTC gene rearrangements and oncogene expression.
    • These findings support the subclassification of HCTs into Hurthle cell adenomas, Hurthle cell carcinomas, and Hurthle cell PTC.
    • This molecular-based subclassification refines the understanding and management of thyroid neoplasms.