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Language disturbances in corticobasal degeneration.

C M Frattali1, J Grafman, N Patronas

  • 1Speech-Language Pathology Section, Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA.

Neurology
|February 26, 2000
PubMed
Summary

Language deficits, including aphasia, are common in corticobasal degeneration (CBD). These language disturbances correlate with specific brain damage patterns, particularly in the left frontal and parietal regions.

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Area of Science:

  • Neurology
  • Neuroscience
  • Speech and Language Pathology

Background:

  • Corticobasal degeneration (CBD) is a progressive neurodegenerative disorder.
  • Language deficits in CBD are not well-characterized.
  • Previous studies suggest cognitive and motor impairments are primary.

Purpose of the Study:

  • To characterize language deficits in corticobasal degeneration (CBD).
  • To investigate the relationship between language impairments and neuroradiologic findings in CBD patients.

Main Methods:

  • A cohort of 15 patients diagnosed with CBD underwent a comprehensive neurobehavioral testing battery.
  • Magnetic Resonance Imaging (MRI) studies were conducted to assess brain structure.
  • Patients were evaluated for the presence and type of aphasia.

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Main Results:

  • Over half of the patients (53%) exhibited classifiable aphasias, such as anomic, Broca's, and transcortical motor aphasias.
  • Aphasias were predominantly linked to damage in the left frontal and parietal cortical areas.
  • Abnormalities in subcortical white matter and the corpus callosum were also associated with language deficits.

Conclusions:

  • Language disturbances are more prevalent in CBD than previously recognized.
  • Specific patterns of cortical and subcortical damage correlate with aphasia in CBD.
  • Detailed language assessments are crucial for understanding CBD's full clinical spectrum.