Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lichenoid and granulomatous dermatitis.

C M Magro1, A N Crowson

  • 1Department of Pathology, Cell Biology, and Anatomy, Medical College of Thomas Jefferson University, Philadelphia, PA, USA.

International Journal of Dermatology
|February 26, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atrophic papulosis: the wedge-shaped skin necrosis overlays an active lesion.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

The differing pathophysiologies that underlie COVID-19-associated perniosis and thrombotic retiform purpura: a case series.

The British journal of dermatology·2020
Same author

Benign atrophic papulosis (Köhlmeier-Degos disease): the wedge-shaped dermal necrosis can resolve with time.

Journal of the European Academy of Dermatology and Venereology : JEADV·2017
Same author

Necrotizing eosinophilic folliculitis: a new manifestation of the atopic diathesis?

Clinical and experimental dermatology·2016
Same author

Hydrogel coated mesh decreases tissue reaction resulting from polypropylene mesh implant: implication in hernia repair.

Hernia : the journal of hernias and abdominal wall surgery·2016
Same author

Laparoscopy shows superiority over endoscopy for early detection of malignant atrophic papulosis gastrointestinal complications: a case report and review of literature.

BMC gastroenterology·2015
Same journal

The "Stamp-n-Tack" Technique: An Ink-Guided Precision Method for Anchoring Tissue After Releasing Facial Retaining Ligaments in Large Facial Flap Reconstruction.

International journal of dermatology·2026
Same journal

Counterfactual Dermatology With Generative Models.

International journal of dermatology·2026
Same journal

Correlation of Clinical and Histopathological Features With Anti-Desmoglein Antibody Profile in Pemphigus Patients.

International journal of dermatology·2026
Same journal

Paracetamol-Induced Generalized Bullous Fixed Drug Eruption With Positive Anti-BP230 Antibody and Confirmed With Oral Provocation Test in a Child: A Case Report From the Philippines.

International journal of dermatology·2026
Same journal

Clinicopathological Challenge: A Painful Violaceous Reticulated Patch.

International journal of dermatology·2026
Same journal

Editor's Highlights-August 2026.

International journal of dermatology·2026
See all related articles

This study identifies a novel lichenoid dermatitis with granulomatous inflammation, often linked to drug reactions, infections, or underlying medical conditions like rheumatoid arthritis. It highlights diverse clinical presentations and histopathological patterns.

Area of Science:

  • Dermatopathology
  • Immunodermatology
  • Histopathology

Background:

  • Lichenoid eruptions are characterized by band-like lymphocytic infiltrates.
  • Traditional lichenoid eruptions include lichen planus, drug reactions, syphilis, and collagen vascular diseases.
  • A novel form of lichenoid dermatitis with a granulomatous component is described.

Purpose of the Study:

  • To characterize a novel lichenoid dermatitis with a granulomatous component.
  • To identify potential triggers and associated medical illnesses.
  • To elucidate the diverse clinical and histopathological features.

Main Methods:

  • Retrospective analysis of 40 skin biopsies over 4 years.
  • Biopsies showed band-like lymphocytic infiltrate with granulomatous inflammation.

Related Experiment Videos

  • Clinical correlation with patient history to identify triggers and comorbidities.

    • Main Results:

    • Diverse clinical presentations included lichenoid dermatitis, linear eruptions, vasculitis, annular erythema, and erythroderma.
    • Identified drug etiology in 14 cases (antibiotics, lipid-lowering agents, etc.).
    • Microbial triggers implicated in 12 patients (herpes zoster, EBV, M. tuberculosis, etc.).
    • Other causes included hepatobiliary disease, rheumatoid arthritis, CTCL, and idiopathic disorders.
    • Histopathological patterns included histiocytic aggregates, granulomata, diffuse interstitial patterns, giant cells, and granulomatous vasculitis.

    Conclusions:

    • Cutaneous lichenoid and granulomatous reactions can be associated with various systemic conditions.
    • Potential triggers include hepatobiliary disease, endocrinopathy, rheumatoid arthritis, Crohn's disease, infections, and drug reactions.
    • Idiopathic lichenoid disorders account for one-fifth of cases.
    • Lymphoproliferative disease or pseudolymphomatous drug reactions should be considered in cases with lymphoid atypia.