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Coronary artery disease and arterial hypertension: clinical, angiographic and follow-up data

A Natali1, S Vichi, P Landi

  • 1Metabolism Unit and the Coronary Division of the C.N.R. Institute of Clinical Physiology, Department of Internal Medicine of the University of Pisa, Pisa, Italy. anatali@ifc.pi.cnr.it

Journal of Internal Medicine
|February 26, 2000
PubMed

Insights

Hypertension increases the likelihood of three-vessel coronary artery disease and non-fatal myocardial infarction in patients with ischaemic heart disease. However, overall prognosis and cardiovascular mortality are only marginally affected by high blood pressure.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Hypertension Research

Background:

  • Arterial hypertension is a significant risk factor for cardiovascular disease.
  • Its specific impact on coronary atherosclerosis and patient prognosis requires detailed evaluation.

Purpose of the Study:

  • To assess the relationship between hypertension and coronary atherosclerosis.
  • To determine the effect of hypertension on the prognosis of patients with ischaemic heart disease.

Main Methods:

  • Retrospective analysis of clinical records and follow-up data from 1700 patients undergoing coronary angiography.
  • Inclusion criteria: patients with or at high risk of ischaemic heart disease.

Main Results:

  • Hypertension was associated with a higher likelihood of three-vessel coronary artery disease (OR=1.41).
  • Hypertensive patients showed increased overall atherosclerotic burden and a higher risk of non-fatal myocardial infarction post-discharge (OR=1.21).
  • Cardiovascular mortality was slightly higher in hypertensives, but not independently significant after adjustment.

Conclusions:

  • Hypertension is a risk factor for the presence of three-vessel coronary artery disease.
  • While coronary stenosis severity and extension were similar, hypertension marginally impacts overall prognosis but increases the risk of non-fatal myocardial infarction.
Abstract

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