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Application of short tandem repeat of genomic DNA and mitochondrial DNA for identification of mixed-up tissue
K Sano1, K Takayanagi, T Kaneko
1Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan. kenjisa@sch.md.shinshu-u.ac.jp
Pathology International
|February 26, 2000
Abstract:
Deoxyribonucleic acid (DNA) typing methods, short tandem repeat of genomic DNA and mitochondrial DNA with the use of polymerase chain reaction amplification, were applied to formalin-fixed, paraffin-embedded tissues submitted for diagnosis, to identify and sort out mixed-up tissue specimens. These techniques were found to be reliable, reproducible and specific for personal identification, and thus to eliminate the need for further examinations and to prevent unnecessary surgery.