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Updated: Aug 2, 2026
08:19
Isolation of Leukocytes from the Human Maternal-fetal Interface
Published on: May 21, 2015
Enhanced expression of intercellular adhesion molecule-1 (ICAM-1) in amnion with term and preterm labour
K W Marvin1, J A Keelan, T A Sato
1Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand. k.marvin@auckland.ac.nz
Placenta
|February 29, 2000
Summary
Intercellular adhesion molecule-1 (ICAM-1) expression in the amnion is significantly elevated during preterm labor and delivery. This finding suggests ICAM-1
Area of Science:
- Reproductive Biology
- Immunology
- Obstetrics
Background:
- Preterm labor and delivery represent a significant challenge in obstetrics.
- The role of specific adhesion molecules in the amnion during labor is not fully understood.
Purpose of the Study:
- To investigate the association between intercellular adhesion molecule-1 (ICAM-1) expression in the human amnion and preterm labor and delivery.
Main Methods:
- ICAM-1 mRNA abundance was assessed using Northern analysis.
- ICAM-1 protein levels were quantified by enzyme-linked immunosorbent assay (ELISA).
- Amniotic tissue samples were collected from women undergoing preterm delivery, spontaneous labor at term, and elective cesarean section before labor.
Main Results:
- ICAM-1 mRNA expression was significantly higher (24-fold) in preterm delivery (PTD) compared to elective cesarean section before term (CST).
- ICAM-1 protein concentration was four-fold greater in PTD samples compared to CST.
- Expression levels were also elevated in spontaneous labor at term (SLT) compared to CST, but less so than in PTD.
Conclusions:
- The human amnion expresses ICAM-1.
- ICAM-1 expression is markedly upregulated in the amnion associated with preterm labor and delivery.
- These findings highlight ICAM-1 as a potential factor in the pathophysiology of preterm birth.
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