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Related Experiment Videos

Advanced glycation end products: a Nephrologist's perspective.

D S Raj1, D Choudhury, T C Welbourne

  • 1Department of Medicine, Lousiana State University Medical Center, Shreveport, LA,USA.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|February 29, 2000
PubMed
Summary

Advanced glycation end products (AGEs) contribute to aging and diabetes complications. Novel agents like aminoguanidine show promise in preventing AGE-related diseases.

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Area of Science:

  • Biochemistry
  • Gerontology
  • Nephrology

Background:

  • Advanced glycation end products (AGEs) are linked to aging, diabetes, and renal failure.
  • AGEs are formed from sugar condensation with proteins and act as uremic toxins.
  • They contribute to vascular and renal complications, and age-related diseases like Alzheimer's.

Purpose of the Study:

  • To explore the role of AGEs in the pathogenesis of aging and diabetes complications.
  • To investigate the accumulation of AGEs in renal failure and their role in dialysis-related amyloidosis.
  • To evaluate potential therapeutic strategies for AGE-related conditions.

Main Methods:

  • Review of in vivo and in vitro studies on AGEs.
  • Analysis of AGE accumulation in aging, diabetes, and renal failure.

Related Experiment Videos

  • Examination of therapeutic agents targeting AGE formation and cross-linking.

    • Main Results:

    • AGEs accelerate atherosclerosis and are implicated in diabetic nephropathy progression.
    • AGEs accumulate in renal failure due to reduced excretion and increased generation.
    • Dialysis cannot normalize AGE levels; islet-cell transplantation can normalize glycosylation.

    Conclusions:

    • AGEs play a critical role in the pathogenesis of diabetes, uremia, and aging complications.
    • Aminoguanidine (AGN) reduces AGE formation and inhibits their action, improving neuropathy and delaying retinopathy/nephropathy.
    • N-Phenacylthiazolium bromide cleaves AGE cross-links, offering potential therapeutic avenues for AGE-related diseases.