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AcrD of Escherichia coli is an aminoglycoside efflux pump
E Y Rosenberg1, D Ma, H Nikaido
1Departments of Molecular and Cell Biology, University of California, Berkeley, California 94720-3206, USA.
Journal of Bacteriology
|February 29, 2000
Abstract:
AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain.