Debilitating chronic pain syndromes after presumed intraneural injections
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Updated: Oct 17, 2026

Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
B R Kaufman1, E Nystrom, S Nath
1Division of Plastic, Reconstructive and Hand Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA.
Abstract:
This report presents seven patients with severe disability established at the time of a peripheral nerve block. In most of the cases, the injection was administered as a routine procedure by an experienced anesthesiologist. The patient histories suggest that the condition, which can be resistant to all treatment, in most cases could have been avoided if careful attention had been given to the occurrence of pain during the nerve block. It is likely that the risk of devastating iatrogenic disability can be minimized if a few basic principles are respected during the administration of peripheral nerve blocks.
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