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Oral gastrografin in neonates: a note of caution
R Tuladhar1, A Daftary, S K Patole
1Department of Neonatology, Kirwan Hospital for Women, Townsville, Australia.
International Journal of Clinical Practice
|February 29, 2000
Abstract:
Hyperosmolar feeds are known to increase gastrointestinal permeability, predisposing to absorption of toxins. They are also associated with necrotising enterocolitis (NEC) in neonates. A case of a neonate with suspected NEC who died following Gram-negative septicaemia possibly related to oral gastrografin is reported. Hyperosmolarity of gastrografin may have caused complete loss of mucosal integrity in the compromised bowel leading to Gram-negative septicaemia.