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Related Experiment Videos

Cystic lymphocytic hypophysitis, visual field defects and hypopituitarism.

J O Farah1, M Rossi, P M Foy

  • 1Walton Centre for Neurology and Neurosurgery, Liverpool, UK.

International Journal of Clinical Practice
|February 29, 2000
PubMed
Summary
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A rare case of cystic pituitary mass in a man led to anterior pituitary failure and vision loss. Surgical removal resolved visual deficits, with histology confirming lymphocytic hypophysitis.

Area of Science:

  • Endocrinology
  • Neurology
  • Pathology

Background:

  • Anterior pituitary failure can manifest with hormonal deficiencies requiring hormone replacement therapy.
  • Pituitary masses can cause mass effect symptoms, including visual field defects and diabetes insipidus.
  • Lymphocytic hypophysitis is an inflammatory condition of the pituitary gland, typically rare in males.

Observation:

  • A 45-year-old male presented with symptoms of anterior pituitary failure, including the need for thyroxine, hydrocortisone, and androgen replacement.
  • Initial MRI revealed a large cystic pituitary mass and pituitary stalk thickening.
  • Over three years, the patient developed diabetes insipidus and bitemporal hemianopia, with observed enlargement of the cystic mass.

Findings:

  • Transsphenoidal resection was performed, resulting in the normalization of visual fields.

Related Experiment Videos

  • Histopathological examination confirmed lymphocytic hypophysitis.
  • The presentation of cystic enlargement in a male patient with lymphocytic hypophysitis is considered unique.

    • Implications:

    • This case expands the understanding of the clinical spectrum of lymphocytic hypophysitis, particularly in male patients.
    • The cystic presentation highlights the importance of comprehensive diagnostic evaluation for pituitary masses.
    • Successful surgical intervention underscores the potential for visual recovery in pituitary mass lesions.