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Malignant hidroacanthoma simplex: a case report.

W J Lee1, Y J Seo, J S Yoon

  • 1Department of Dermatology, Chungnam National University School of Medicine, Taejon, Korea.

The Journal of Dermatology
|February 29, 2000
PubMed
Summary
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Malignant transformation of hidroacanthoma simplex, a benign skin tumor, is rare. This case highlights a pigmented hidroacanthoma with malignant changes, emphasizing the need for vigilance in diagnosing skin lesions.

Area of Science:

  • Dermatology
  • Oncology

Background:

  • Hidroacanthoma simplex is a benign skin tumor originating from sweat glands.
  • It typically presents as an intraepidermal growth of epithelial cells.
  • Malignant transformation of this tumor is uncommon.

Observation:

  • A rare case of pigmented hidroacanthoma simplex with malignant transformation is presented in a 67-year-old woman.
  • The lesion on the right thigh had a 20-year history, evolving from a papule to a pigmented plaque.

Findings:

  • Histological examination revealed a tumor composed of small squamoid cells with marked cellular atypia, predominantly intraepidermal.
  • Immunohistochemistry showed positive staining for epithelial membrane antigen in some tumor cells, but negative for carcino-embryonic antigen and S-100 protein.

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Implications:

  • This case underscores the potential for malignant transformation in hidroacanthoma simplex, even in pigmented variants.
  • Accurate histological and immunohistochemical evaluation is crucial for diagnosing and managing such rare skin neoplasms.