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Updated: Aug 16, 2026

A Method for Ovarian Follicle Encapsulation and Culture in a Proteolytically Degradable 3 Dimensional System
Published on: March 15, 2011
Plasmin-tumour necrosis factor interaction in the ovulatory process
1Department of Animal Science, University of Wyoming, Laramie 82071, USA.
Abstract:
Collagen breakdown and apoptotic cell death within the apex of the preovulatory ovine follicle are hallmarks of impending ovarian rupture. An integrative mechanism is proposed whereby gonadotrophic stimulation of urokinase-type plasminogen activator secretion by the follicular-contiguous ovarian surface epithelium elicits a localized increase in tissue plasmin, which activates collagenolysis and tumour necrosis factor alpha-induced cell death within the formative ovulatory stigma.
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