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Plasmin-tumour necrosis factor interaction in the ovulatory process.

¹Department of Animal Science, University of Wyoming, Laramie 82071, USA.

Journal of Reproduction and Fertility. Supplement

|February 29, 2000

Summary

Ovarian rupture involves collagen breakdown and cell death in ovine follicles. Gonadotropins stimulate the ovarian surface epithelium to release enzymes that trigger these processes in the ovulatory stigma.

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Area of Science:

Reproductive Biology
Cellular Biology
Biochemistry

Background:

Collagen degradation and apoptosis are key events preceding ovulation in ovine follicles.
The ovulatory stigma is the site of follicular rupture.

Purpose of the Study:

To elucidate the integrative mechanism linking gonadotrophic stimulation to collagenolysis and apoptosis in the ovine ovulatory stigma.

Main Methods:

The study proposes a mechanism involving gonadotrophic stimulation, urokinase-type plasminogen activator secretion, and tissue plasmin activity.
Investigated the role of plasmin in activating collagenolysis and tumor necrosis factor alpha-induced cell death.

Main Results:

Gonadotrophic stimulation of the ovarian surface epithelium increases urokinase-type plasminogen activator secretion.
This leads to localized tissue plasmin, which activates collagen breakdown and tumor necrosis factor alpha-induced apoptosis in the ovulatory stigma.

Conclusions:

A proposed mechanism integrates gonadotropin action with local enzymatic activity to orchestrate follicular rupture.
This process involves collagenolysis and programmed cell death at the ovulatory stigma site.

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