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Updated: Oct 17, 2026

Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies
Published on: December 15, 2014
[Changes in the direct and interhemispheric responses of the pyramidal tract after tetanization of the cortex and
R G Kozhedub1, V A Zosimovskiĭ, A N Balashova
1Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Abstract:
Changes in pyramidal tract response after unilateral neocortical and lateral hypothalamic tetanization were analyzed in unanesthetized and nonimmobilized rabbits. Membrane and synaptic modifications were revealed in intra- and interhemispheric connections. Changes in excitability of callosal collaterals of pyramidal tract neurons in contralateral hemisphere and changes in somatodendritic excitability in ipsilateral hemisphere could be oppositely directed. Plasticity of callosal connections may contribute to the interhemispheric asymmetry during learning.
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