Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Humoral immunity in human sarcomas].

S I Sergeev, V M Bergol'ts, B N Kovalev

    Voprosy Onkologii
    |January 1, 1976
    PubMed
    Summary

    Cytotoxic antibodies in sarcoma patients

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [The organizational problems of cancer care today].

    Voprosy onkologii·1995
    Same author

    [Cooperative studies on the treatment of breast neoplasms, stage I, IIA, IIB and IIIB].

    Sovetskaia meditsina·1990
    Same author

    [Results of combined treatment of cancer of the gastric antrum and gastric body].

    Voprosy onkologii·1990
    Same author

    [The complex system of evaluating scientific research work in public health and medicine].

    Sovetskaia meditsina·1990
    Same author

    [Ways of solving the problems of the control of malignant neoplasms in the RSFSR].

    Sovetskaia meditsina·1989
    Same author

    [Improving the organization of services for patients with malignant neoplasms of the head and neck].

    Sovetskaia meditsina·1989

    Area of Science:

    • Immunology
    • Oncology

    Context:

    • Humoral immunity in sarcoma patients was investigated.
    • Cytotoxic testing utilized a human mesenchymoma cell line.

    Purpose:

    • To assess serum and immunoglobulin fraction activity in sarcoma patients.
    • To identify cytotoxic antibodies and their behavior during treatment.

    Summary:

    • 19S immunoglobulin fractions in patient serum contained cytotoxic antibodies, while 7S fractions were inactive.
    • Whole serum showed cytotoxicity in most soft tissue sarcoma patients before treatment.
    • Immunoglobulins exhibited specific binding to target cells, suggesting cytotoxic and potential blocking effects.
    • Irradiation treatment did not reduce the cytotoxic activity of serum or its 19S fraction.

    Impact:

    • Findings contribute to understanding anti-tumor immunity in sarcoma.
    • Highlights the role of 19S immunoglobulins in cytotoxic responses.
    • Suggests potential for immunotherapy targeting immunoglobulin activity in sarcoma.