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Related Experiment Videos

Creatine enhances oxygen uptake and performance during alternating intensity exercise.

J Rico-Sanz1, M T Mendez Marco

  • 1Department of Biochemistry and Molecular Biology, Faculty of Sciences, University Autonoma of Barcelona, Spain. j.rico-sanz@proton.uab.es

Medicine and Science in Sports and Exercise
|February 29, 2000
PubMed
Summary

Creatine supplementation enhances exercise performance in well-trained males by increasing oxygen consumption and reducing blood metabolite accumulation. This leads to improved work capacity during high-intensity interval training.

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Area of Science:

  • Exercise Physiology
  • Nutritional Biochemistry
  • Sports Science

Background:

  • Creatine supplementation is widely used to enhance athletic performance.
  • Understanding the physiological effects of creatine loading in well-trained individuals is crucial for optimizing training protocols.

Purpose of the Study:

  • To evaluate the impact of creatine (Cr) loading on oxygen consumption, blood metabolite accumulation, and exercise performance.
  • To compare these effects before and after a 5-day creatine loading period in well-trained males.

Main Methods:

  • Fourteen well-trained males underwent 5 days of either placebo (PL) or creatine monohydrate (CR) loading (20 g/day).
  • Participants performed intermittent high-intensity cycle exercise (30% and 90% maximal power output) to exhaustion.

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  • Oxygen uptake was measured continuously, and blood samples were collected at various time points.

    • Main Results:

    • Creatine loading significantly increased total oxygen consumed during high-intensity exercise.
    • Blood ammonia and uric acid accumulation were reduced following creatine loading.
    • Time to exhaustion increased significantly after creatine loading, indicating improved endurance.

    Conclusions:

    • Creatine supplementation enhances the muscle's capacity to perform work during alternating intensity exercise.
    • These improvements may be attributed to increased aerobic phosphorylation and creatine kinase system flux.
    • Creatine loading offers a viable ergogenic aid for well-trained athletes seeking performance enhancement.