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Relationship between blood pressure level and mortality rate: an 18-year study conducted in two rural communities in

S Takagi1, S Saitoh, M Nakano

  • 1Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan. takagis@sapmed.ac.jp

Journal of Hypertension
|February 29, 2000
PubMed

Insights

Cardiovascular disease mortality risk increases with higher blood pressure in Japanese adults. Treatment for hypertension should ideally begin when blood pressure reaches 140/90 mmHg or less.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Limited research exists on cardiovascular disease prognosis based on blood pressure levels in the Japanese population.
  • Hypertension management in Japan faces challenges regarding optimal timing for initiating treatment despite medication availability.

Purpose of the Study:

  • To examine the long-term cardiovascular disease prognosis in the Japanese general population stratified by blood pressure.
  • To identify the blood pressure thresholds associated with increased cardiovascular mortality risk.

Main Methods:

  • A prospective community-based cohort study followed 1996 adults (40-64 years) for 18 years.
  • Data on mortality and causes of death were collected via public health nurses, death certificates, and physician questionnaires.
  • Analysis correlated baseline blood pressure categories with cardiovascular disease mortality.

Main Results:

  • Cardiovascular disease mortality significantly increased with higher systolic blood pressure (≥140 mmHg) and diastolic blood pressure (≥90 mmHg).
  • Adjusted analyses confirmed this association, considering age, sex, and other cardiovascular risk factors.
  • No J-shaped relationship was observed between blood pressure levels and cardiovascular disease mortality risk.

Conclusions:

  • The findings suggest that initiating hypertension treatment when blood pressure is 140/90 mmHg or lower is optimal for the Japanese population.
  • This threshold aims to mitigate the increased risk of cardiovascular disease mortality associated with elevated blood pressure.
Abstract

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