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Update on gastroesophageal reflux and respiratory disease in children

S R Orenstein1

  • 1Children's Hospital of Pittsburgh, Pittsburgh, USA. orensts@chplink.chp.edu

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
|February 29, 2000
PubMed

Insights

Gastroesophageal reflux disease (GERD) is linked to pediatric respiratory issues like apnea and asthma. Understanding the connection between the digestive and respiratory tracts is key to diagnosing and treating these conditions.

Area of Science:

  • Pediatric Pulmonology
  • Gastroenterology

Background:

  • Pediatric respiratory diseases, including infantile apnea and childhood asthma, are increasingly associated with gastroesophageal reflux disease (GERD).
  • The complex relationship and underlying mechanisms require further investigation.

Purpose of the Study:

  • To review the evidence linking GERD to infantile apnea and childhood asthma.
  • To explore the embryological and physiological connections between the upper gastrointestinal and respiratory tracts.
  • To examine protective mechanisms against GERD-induced respiratory symptoms.

Main Methods:

  • Literature review of studies investigating the association between GERD and pediatric respiratory disorders.
  • Analysis of embryological and physiological data related to the gastrointestinal and respiratory systems.
  • Examination of clinical challenges in diagnosing and treating these conditions.

Main Results:

  • Evidence supports an association between GERD and common pediatric respiratory conditions such as infantile apnea and asthma.
  • Embryological and physiological links between the gastrointestinal and respiratory tracts provide a basis for this association.
  • Dysfunction in protective mechanisms may explain the pathophysiology of GERD-related respiratory manifestations.

Conclusions:

  • GERD is a significant factor in pediatric respiratory diseases like apnea and asthma.
  • Understanding the anatomical and physiological interplay is crucial for effective diagnosis and treatment.
  • Further research into protective mechanisms could reveal novel therapeutic targets.

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