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Related Experiment Videos

Tumoral calcinosis: a case report with an electron microscopic study.

J Arikawa1, Y Higaki, J Mizushima

  • 1Department of Dermatology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 Japan.

European Journal of Dermatology : EJD
|February 29, 2000
PubMed
Summary

A traumatic bruise led to painful subcutaneous calcification in a woman. The condition involved hydroxyapatite deposition on proteoglycans, suggesting vascular injury and hypoxia contribute to calcinosis.

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Area of Science:

  • Dermatology
  • Pathology
  • Vascular Biology

Background:

  • Subcutaneous calcification can occur following trauma.
  • Understanding the pathogenesis of calcinosis is crucial for effective treatment.

Observation:

  • A 68-year-old woman presented with painful subcutaneous masses after a bruise.
  • Histology revealed extensive dermal calcification, identified as hydroxyapatite deposition.
  • Electron microscopy showed crystalline material on unusual proteoglycans and thickened basement membranes in vessels.

Findings:

  • The patient's calcinosis was linked to vascular injury and subsequent hypoxia.
  • The calcification process involved hydroxyapatite deposition on proteoglycans.
  • Thickened basement membranes in vessel walls suggest a role for vascular changes.

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Implications:

  • This case highlights a potential mechanism for post-traumatic calcinosis.
  • Vascular integrity and oxygenation may be key factors in preventing or treating calcinosis.
  • Surgical intervention can provide symptomatic relief for painful subcutaneous calcification.