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The use of systemic antimycotics in dermatotherapy.
1Dermatologische Klinik und Poliklinik, Ludwig-Maxamilians-Universität, Frauenlob-strasse 9-11, D-80337 München, Germany.
European Journal of Dermatology : EJD
|February 29, 2000
Summary
Effective treatment of fungal infections, including skin, nail, and hair mycoses, requires individualized systemic therapy for severe cases. Newer antifungal drugs like azoles and terbinafine offer better options than older medications.
Area of Science:
- Dermatology
- Mycology
- Pharmacology
Background:
- Fungal infections (mycoses) of the skin, nails, and hair are prevalent dermatological conditions.
- Effective treatment of mycoses can be challenging, particularly in extensive or resistant cases.
Purpose of the Study:
- To review current therapeutic strategies for fungal infections.
- To highlight the importance of individualized treatment approaches.
Main Methods:
- Review of systemic and topical antifungal therapies.
- Comparison of older and newer antifungal agents.
- Discussion of treatment selection criteria.
Main Results:
- Topical therapy suffices for mild cases; systemic therapy is essential for extensive, hyperkeratotic, or onychomycotic infections.
- Azoles (itraconazole, fluconazole) and terbinafine are key systemic treatments.
- Older antifungals like griseofulvin and ketoconazole are less frequently used.
Conclusions:
- Optimal antifungal therapy requires tailoring to the individual patient's situation, considering drug type and administration.
- Treatment selection should prioritize the best benefit-to-risk and benefit-to-cost ratios.
- Complete cure may not always be achievable.