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Related Experiment Videos

SAP family proteins.

A Fujita1, Y Kurachi

  • 1Department of Pharmacology II, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.

Biochemical and Biophysical Research Communications
|March 1, 2000
PubMed
Summary
This summary is machine-generated.

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Five members of the Synapse Associated Protein (SAP) family are identified. This review summarizes their structures and functions in both neuronal and epithelial cells.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • The Synapse Associated Protein (SAP) family comprises five identified members: Dlg, SAP97/hDlg, SAP90/PSD-95, SAP102, and PSD-93/chapsyn110.
  • These proteins are crucial for the localization and function of glutamate receptors and K(+) channels.
  • While predominantly found at synapses, SAP97 exhibits expression in epithelial cells.

Purpose of the Study:

  • To review the structural characteristics of SAP family proteins.
  • To discuss the diverse functions of SAP proteins in both neuronal and epithelial cells.

Main Methods:

  • Literature review of existing studies on SAP family proteins.

Main Results:

  • Detailed summary of the structural features of the five SAP family members.

Related Experiment Videos

  • Elucidation of the roles these proteins play in synaptic function.
  • Highlighting the unique expression and potential functions of SAP97 in epithelial cells.

    • Conclusions:

    • SAP family proteins possess distinct structural attributes.
    • These proteins are vital for neuronal signaling and ion channel regulation.
    • SAP97 represents a unique member with implications beyond neuronal function, extending to epithelial biology.