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[Adrenal function in chronic myeloid leukemia].

M Podolak-Dawidziak, D Silber-Kasprzak

    Acta Haematologica Polonica
    |October 1, 1976
    PubMed
    Summary
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    This study found that chronic myeloid leukemia and Busulphan treatment did not impair adrenal function in patients. Adrenal reserve appears maintained, even during blastic crisis, suggesting Busulphan

    Area of Science:

    • Endocrinology
    • Hematology
    • Pharmacology

    Context:

    • Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm.
    • Busulphan is an alkylating agent used in CML treatment.
    • Adrenal function assessment is crucial for patients undergoing long-term therapy.

    Purpose:

    • To evaluate adrenal cortical and medullary function in CML patients treated with Busulphan.
    • To determine if CML or Busulphan therapy impacts adrenal function.
    • To investigate adrenal reserve in patients with CML, including those in blastic crisis.

    Summary:

    • Adrenocortical function was assessed via plasma 11-hydroxysteroids (11-OHCS) and urinary 17-hydroxysteroids (17-OHCS).
    • Adrenomedullary function was evaluated by measuring urinary 24-hour VMA levels.

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  • Most patients exhibited normal adrenal function markers; elevated levels were noted in some, particularly those with blastic crisis, suggesting preserved adrenal reserve.

    • Impact:

    • Findings indicate that neither CML nor Busulphan treatment significantly impairs adrenal function.
    • The study suggests that adrenal reserve is maintained in CML patients, even during disease progression.
    • Further research into Busulphan's potential direct effects on melanin metabolism is warranted.