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Related Experiment Videos

CD44 cell adhesion molecules.

S Goodison1, V Urquidi, D Tarin

  • 1UCSD Cancer Center, University of California, La Jolla 92093-0658, USA.

Molecular Pathology : MP
|March 1, 2000
PubMed
Summary

CD44 proteins are cell surface molecules crucial for tissue structure and cell adhesion. Their variants are increasingly recognized as potential diagnostic markers and therapeutic targets in cancer.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • CD44 proteins are ubiquitously expressed cell surface adhesion molecules.
  • They are generated from a single gene through alternative splicing and post-translational modifications.
  • CD44 mediates cell-cell and cell-matrix interactions, primarily binding hyaluronic acid.

Purpose of the Study:

  • To review the structure of the CD44 gene.
  • To discuss the physiological and pathological roles of CD44.
  • To highlight CD44's potential as a cancer biomarker and therapeutic target.

Main Methods:

  • Literature review of CD44 gene structure, protein isoforms, and functions.
  • Analysis of CD44's role in physiological processes like tissue structure maintenance.
  • Examination of CD44's involvement in pathological conditions, particularly neoplasia.

Main Results:

  • CD44 proteins exhibit diverse isoforms with conserved structures across mammals.
  • CD44 plays a key role in tissue integrity and immune cell homing.
  • Upregulation of CD44 isoforms, especially variants, is observed in various cancers.

Conclusions:

  • CD44 is vital for tissue homeostasis and has implications in immune responses.
  • Altered CD44 expression, particularly variants, signifies malignancy.
  • CD44 represents a promising target for cancer diagnostics and therapeutics.

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