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[Distribution and features of infection with hepatitis viruses B and C during hemodialysis treatment]

M L Zubkin, N A Selivanov, V M Stakhanova

    Voprosy Virusologii
    |March 1, 2000
    PubMed

    Insights

    Hepatitis B and C infections are common in hemodialysis patients, with chronic hepatitis C affecting 24%. Viral replication is high, and infection risk increases with dialysis duration.

    Area of Science:

    • Hepatology
    • Infectious Diseases
    • Nephrology

    Context:

    • Hemodialysis patients face a high risk of viral hepatitis infections.
    • Understanding hepatitis B (HBV) and hepatitis C (HCV) prevalence is crucial for this vulnerable population.

    Purpose:

    • To evaluate the prevalence and characteristics of HBV and HCV infections in hemodialysis patients.
    • To analyze the relationship between infection timelines and dialysis duration.

    Summary:

    • 48% of 140 hemodialysis patients experienced resolved acute hepatitis B; 6% had chronic hepatitis B, and 24% had chronic hepatitis C.
    • Hepatitis C genotype 1b was predominant (73%). HBV and HCV replication occurred in 83% and 86% of patients, respectively.
    • HBV infection occurred sooner (16 months) than HCV infection (30 months) after starting hemodialysis.

    Impact:

    • Highlights the significant burden of HBV and HCV in hemodialysis settings.
    • Suggests a need for enhanced screening and prevention strategies for hepatitis in dialysis units.
    • Provides insights into the temporal dynamics of HBV and HCV acquisition during hemodialysis.

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