Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The oxygen trail: tissue oxygenation.

A T Nathan1, M Singer

  • 1Bloomsbury Institute of Intensive Care Medicine, University College London Medical School, UK.

British Medical Bulletin
|March 1, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Injection, confinement, and diagnosis of electrons and positrons in a permanent magnet dipole trap.

The European physical journal. D, Atomic, molecular, and optical physics·2024
Same author

The utility of parathyroid autofluorescence as an adjunct in thyroid and parathyroid surgery 2023.

Head & neck·2023
Same author

Difficult diagnosis in the ICU: making the right call but beware uncertainty and bias.

Anaesthesia·2023
Same author

Reducing broad-spectrum antibiotic use in intensive care unit between first and second waves of COVID-19 did not adversely affect mortality.

The Journal of hospital infection·2022
Same author

Non-neutral plasma manipulation techniques in development of a high-capacity positron trap.

The Review of scientific instruments·2022
Same author

The profiling of microbiota in vaginal swab samples using 16S rRNA gene sequencing and IS-pro analysis.

BMC microbiology·2021
Same journal

Human health in relation to visible, functional, and accessible green space: a systematic review and narrative synthesis of the 3 + 30 + 300 guideline.

British medical bulletin·2026
Same journal

Muscle herniae in exercise-induced leg pain: diagnostic pitfalls and the 'repair paradox'.

British medical bulletin·2026
Same journal

Scaffolds and platelet concentrates in bone regenerative medicine: applications, mechanisms, and future approaches.

British medical bulletin·2026
Same journal

Back squat and deadlift fatiguing protocols elicit distinct countermovement jump profiles: phase-specific predictors and soreness responses.

British medical bulletin·2026
Same journal

Enhancing bone healing through osteogenic medium components: biological roles, mechanisms, and clinical applications.

British medical bulletin·2026
Same journal

Moral injury in healthcare workers: causes & interventions.

British medical bulletin·2026
See all related articles

This review explores how the body maintains oxygen supply for aerobic respiration, focusing on the interplay between respiratory and circulatory systems to ensure cellular survival.

Area of Science:

  • Physiology
  • Cellular Biology
  • Biochemistry

Background:

  • Aerobic cellular respiration requires efficient oxygen and substrate delivery to mitochondria.
  • Oxygen transport involves a cascade from the environment to the subcellular level.
  • Circulatory and respiratory systems coordinate to ensure oxygen delivery, influenced by neural and humoral factors.

Purpose of the Study:

  • To explore the mechanisms the body uses to maintain tissue oxygen levels.
  • To understand how optimal oxygen levels for cell survival are achieved.
  • To review the body's response to hypoxia and its impact on cellular function.

Main Methods:

  • Review of existing literature on oxygen transport and cellular respiration.
  • Analysis of physiological mechanisms controlling oxygen delivery.

Related Experiment Videos

  • Examination of cellular responses to hypoxia and reactive oxygen species.

    • Main Results:

    • Oxygen delivery relies on coordinated respiratory and circulatory function, with local autoregulation by metabolic factors.
    • Hypoxia triggers responses including cytokine activation and genetic factors to enhance perfusion and regulate metabolism.
    • Reactive oxygen species formation during hypoxia can impair mitochondrial function, leading to cell death.

    Conclusions:

    • The body employs complex mechanisms involving systemic and local controls to maintain oxygen homeostasis.
    • Understanding these mechanisms is crucial for addressing conditions of impaired oxygen supply.
    • Cellular responses to hypoxia, while protective, can also lead to detrimental effects if reactive oxygen species are overproduced.