Related Experiment Videos
Funalenone, a novel collagenase inhibitor produced by Aspergillus niger
J Inokoshi1, K Shiomi, R Masuma
1School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
The Journal of Antibiotics
|March 1, 2000
Abstract:
Funalenone, a phenalene compound that inhibits type I collagenase (MMP-1), was isolated from mycelium of Aspergillus niger FO-5904 by solvent extaction, ODS column chromatography, Sephadex LH-20 column chromatography and reversed phase HPLC. Funalenone inhibited 50% of type I collagenase activity at a concentration of 170 microM, but inhibited 18.3% and 38.7% against 72 kDa and 92 kDa type IV collagenase, respectively, at a concentration of 400 microM.