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The Colorado thyroid disease prevalence study.

G J Canaris1, N R Manowitz, G Mayor

  • 1Department of Medicine, University of Nebraska Medical Center, Omaha 68198-3331, USA. gcanaris@unmc.edu

Archives of Internal Medicine
|March 1, 2000
PubMed
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Abnormal thyroid function is common, affecting 9.5% of the population. Mild thyroid dysfunction is linked to increased cholesterol, highlighting the importance of thyroid-stimulating hormone (TSH) testing for cardiovascular health.

Area of Science:

  • Endocrinology
  • Public Health
  • Clinical Medicine

Background:

  • Thyroid dysfunction prevalence and systemic effects, especially mild thyroid failure, remain debated.
  • The correlation between hypothyroid symptoms and biochemical thyroid function is not well-established.
  • Accurate assessment requires sensitive diagnostic tools.

Purpose of the Study:

  • To ascertain the prevalence of abnormal thyroid function.
  • To investigate the relationship between abnormal thyroid function and lipid profiles.
  • To examine the association between abnormal thyroid function and reported symptoms using sensitive thyroid tests.

Main Methods:

  • A cross-sectional study design was employed.
  • Data collected from 25,862 participants at a 1995 Colorado health fair.

Related Experiment Videos

  • Assessed serum thyrotropin (TSH), total thyroxine (T4), lipid levels, and hypothyroid symptom questionnaires.

    • Main Results:

    • Elevated TSH (thyroid dysfunction) prevalence was 9.5%; decreased TSH was 2.2%.
    • Forty percent of patients on thyroid medication had abnormal TSH levels.
    • Declining thyroid function correlated with increased lipid levels, notably total and LDL cholesterol, even with mild TSH elevations (5.1-10 mIU/L).
    • Hypothyroid individuals reported more symptoms, but individual symptom sensitivity was low.

    Conclusions:

    • The study confirms a substantial prevalence of abnormal thyroid function, consistent with smaller studies.
    • A significant portion of patients on thyroid medication (40%) had suboptimal TSH levels.
    • Subtle TSH elevations are associated with lipid changes impacting cardiovascular health.
    • While individual symptoms lack sensitivity, multiple symptoms warrant thyroid testing.
    • Thyroid dysfunction is common, often undetected, and linked to adverse outcomes preventable by TSH testing.