Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hematologic toxicity of sodium valproate.

S Acharya1, J B Bussel

  • 1Department of Pediatric Hematology/Oncology, New York Presbyterian Hospital-Cornell Medical Center, New York 10021, USA.

Journal of Pediatric Hematology/Oncology
|March 1, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for Light Pseudoscalar Bosons, Pair-Produced in Higgs Boson Decays in the Four-Electron Final State in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

First Evidence for Mixing-Induced CP Violation in B_{s}^{0}→J/ψϕ(1020) Decays in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

Observation of Suppressed Charged-Particle Production in Ultrarelativistic Oxygen-Oxygen Collisions.

Physical review letters·2026
Same author

Measurement of D^{0} Meson Photoproduction in Ultraperipheral Heavy Ion Collisions.

Physical review letters·2026
Same author

Observation of tWZ Production at the CMS Experiment.

Physical review letters·2026
Same author

First Exclusive Reconstruction of the B^{*+}, B^{*0}, and B_{s}^{*0} Mesons and Precise Measurement of Their Masses.

Physical review letters·2026

Sodium valproate can cause hematologic toxicities like bone marrow suppression and bleeding issues. Monitoring and dosage adjustments are key for managing these common side effects in epilepsy patients.

Area of Science:

  • Hematology
  • Pharmacology
  • Pediatric Neurology

Background:

  • Sodium valproate is a widely used anticonvulsant for refractory childhood epilepsy.
  • Hepatotoxicity is a known side effect, but hematologic toxicity is increasingly recognized with higher doses.
  • Pediatric hematologists are often consulted for valproate-induced hematologic issues, especially in pre- or perioperative settings.

Purpose of the Study:

  • To characterize the hematologic toxicities associated with sodium valproate.
  • To provide management guidelines for patients experiencing these toxicities.

Main Methods:

  • A literature review was conducted.
  • Searched for studies on valproate (monotherapy or polytherapy) focusing on hematology and bleeding.

Related Experiment Videos

Main Results:

  • Valproate can cause bone marrow suppression, aplastic anemia, and cytopenias (thrombocytopenia, neutropenia, red cell aplasia).
  • Rarely, it may lead to fatal bone marrow failure, myelodysplasia, or acute promyelocytic leukemia-like presentations.
  • A bleeding diathesis can occur due to thrombocytopenia, impaired platelet function, and acquired von Willebrand disease.

Conclusions:

  • Hematologic toxicities are common, variable, and often linked to serum levels >100 microg/mL.
  • Most toxicities are reversible with dose reduction; discontinuation is rare.
  • Lifelong quarterly laboratory monitoring for thrombocytopenia and leukopenia is recommended.
  • Preoperative coagulation studies and potential perioperative DDAVP use are advised for surgical patients.