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Related Experiment Videos

Prothrombotic abnormalities in children with venous thromboembolism.

M Bonduel1, M Hepner, G Sciuccati

  • 1Hematology-Oncology Department, Hospital de Pediatría, Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina.

Journal of Pediatric Hematology/Oncology
|March 1, 2000
PubMed
Summary

A high frequency of prothrombotic disorders was found in children with venous thromboembolism (VTE). A complete hemostatic evaluation is recommended for all pediatric VTE patients to identify inherited or acquired conditions.

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Area of Science:

  • Pediatric Hematology
  • Thrombosis Research
  • Vascular Medicine

Background:

  • Venous thromboembolism (VTE) in children is a significant clinical concern.
  • Identifying underlying prothrombotic disorders is crucial for management and prevention.

Purpose of the Study:

  • To determine the prevalence of acquired and inherited prothrombotic disorders in pediatric patients diagnosed with VTE.
  • To assess the frequency of these disorders in relation to identified risk factors.

Main Methods:

  • Prospective study of 56 consecutive pediatric patients with VTE over a six-year period (1992-1998).
  • Evaluation included assessment of risk factors, family history, and specific laboratory testing for prothrombotic conditions.

Main Results:

Related Experiment Videos

  • A high rate of risk factors (96%) and prothrombotic disorders (46%) was observed in the pediatric VTE cohort.
  • Commonly detected inherited disorders included protein C deficiency, protein S deficiency, and Factor V Leiden mutation.
  • Acquired disorders such as antiphospholipid antibodies and antithrombin deficiency were also frequently identified.

Conclusions:

  • A substantial proportion of children with VTE have underlying prothrombotic disorders, both inherited and acquired.
  • Comprehensive hemostatic evaluation is essential for all pediatric VTE cases, irrespective of the presence of other risk factors.