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Use of 99mTc-mercaptoacetyltriglycine to evaluate renal function in horses
P R Woods1, W T Drost, C R Clarke
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, USA.
Abstract:
Ten healthy horses were injected intravenously with 99mTc-MAG3 and the disappearance of radioactivity from the blood was measured. The total body clearance (Cl(B)) and elimination half-life (t1/2(beta)) were 7.9 +/- 1.5 ml/kg/minute and 32.8 +/- 4.1 minutes, respectively. The disappearance of 99mTc-MAG3 from the blood of 2 horses with compromised renal function was also measured. The data suggest that 99mTc-MAG3 is a useful and clinically applicable radiopharmaceutical for measurement of effective renal blood flow in the horse.