Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neo-osseous flaps using demineralized allogeneic bone in a rat model.

J H Lee1, C P Cornelius, N Schwenzer

  • 1Department of Oral & Maxillofacial Surgery, College of Dentistry, Seoul National University, Chong-nogu, Korea.

Annals of Plastic Surgery
|March 1, 2000
PubMed
Summary

Demineralized allogeneic bone (DALB) shows potential as a bone graft substitute, demonstrating consistent bone formation and neovascularization. While bone regeneration is slower than with autologous bone (AUB), DALB neoflaps exhibit higher blood flow, suggesting long-term suitability.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The influence of dexamethasone on postoperative swelling and neurosensory disturbances after orthognathic surgery: a randomized controlled clinical trial.

Head & face medicine·2017
Same author

Magnetic resonance imaging: a useful tool to distinguish between keratocystic odontogenic tumours and odontogenic cysts.

The British journal of oral & maxillofacial surgery·2015
Same author

[New applications in maxillofacial surgery: Local injections with botulinum toxin type A].

Mund-, Kiefer- und Gesichtschirurgie : MKG·2013
Same author

[The influence of early fronto-orbital advancement on the growth of the frontal sinus and supraorbital region].

Mund-, Kiefer- und Gesichtschirurgie : MKG·2013
Same author

[Craniofacial techniques in traumatology].

Mund-, Kiefer- und Gesichtschirurgie : MKG·2013
Same author

[Custom-made ceramic implants for reconstruction of the bony orbit using a dental copy milling unit].

Mund-, Kiefer- und Gesichtschirurgie : MKG·2013

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Vascular Biology

Background:

  • Surgical reconstruction using revascularized bone grafts faces limitations in donor tissue availability.
  • Bone substitutes offer a promising alternative for prefabricating compound neoflaps.

Purpose of the Study:

  • To evaluate the suitability of demineralized allogeneic bone (DALB) slabs for fabricating neo-osseous flaps.
  • To compare DALB-based neoflaps with those using autologous bone (AUB) in a rat model.

Main Methods:

  • Fabrication of neo-osseous flaps using DALB and AUB in 45 rats.
  • Assessment of histological bone formation and neovascularization via microangiography and polyfluorochrome labeling.
  • Quantitative blood flow measurement using radiolabeled microspheres at 8 weeks.

Related Experiment Videos

Main Results:

  • DALB neoflaps exhibited consistent bone formation and neovascularization, though bone regeneration was slower than in AUB neoflaps.
  • No significant differences in vascularization were observed between DALB and AUB neoflaps across all time points.
  • DALB neoflaps demonstrated significantly higher bone blood flow per dry weight compared to AUB and intact iliac bone.

Conclusions:

  • Demineralized allogeneic bone (DALB) is a potential substitute for autologous bone (AUB) in creating prefabricated neo-osseous flaps.
  • Elevated blood flow in DALB neoflaps may indicate ongoing bone formation, suggesting long-term viability.
  • Further research is needed to fully elucidate the implications of enhanced blood flow in DALB grafts.