Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparison of two serotype 1 MDV isolates.

A M Miles1, A S Anderson, E L Bernberg

  • 1Delaware Agricultural Experiment Station, Department of Animal and Food Sciences, College of Agricultural Sciences, University of Delaware, Newark 19717-1303, USA.

Acta Virologica
|March 4, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genotypic and phenotypic comparison of Neisseria meningitidis carriage and invasive disease isolates contemporaneously collected in the Netherlands.

FEMS microbiology letters·2025
Same author

Evaluating post-cardiac arrest blood pressure thresholds associated with neurologic outcome in children: Insights from the pediRES-Q database.

Resuscitation·2024
Same author

'<i>It was called a grab bag and nobody wanted to grab them'</i>: Teachers' perceptions of school lunches during the COVID-19 pandemic - a regional case study.

Journal of public health research·2023
Same author

Co-designed weight management intervention for women recovering from oestrogen-receptor positive breast cancer.

BMC cancer·2022
Same author

Near-infrared spectroscopy during cardiopulmonary resuscitation for pediatric cardiac arrest: A prospective, observational study.

Resuscitation·2022
Same author

Heart transplantation outcomes in cardiac sarcoidosis.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2021
Same journal

A novel deltacryptic virus identified in Allium cepa from Brazil.

Acta virologica·2023
Same journal

Kinetics of interferon-λ and receptor expression in response to in vitro respiratory viral infection.

Acta virologica·2023
Same journal

High resolution melting curve analysis for rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants.

Acta virologica·2023
Same journal

Attenuation of equine herpesvirus 1 through deletion of gE gene and its pathological evaluation in murine model.

Acta virologica·2023
Same journal

Instrument-free, visual and direct detection of porcine reproductive and respiratory syndrome viruses in resource-limited settings.

Acta virologica·2023
Same journal

Structural and functional characterization of SARS-CoV-2 nucleocapsid protein mutations identified in Turkey by using in silico approaches.

Acta virologica·2023
See all related articles

Marek's disease virus (MDV) serotype 1 isolates were compared. The T. King (TK) isolate caused more damage, but was later found to be contaminated with chicken infectious anemia virus (CIAV).

Area of Science:

  • Poultry Virology
  • Immunology
  • Animal Pathology

Background:

  • Marek's disease virus (MDV) causes significant economic losses in the poultry industry.
  • Understanding the pathogenicity of different MDV serotypes and isolates is crucial for effective disease control.
  • Previous comparisons of MDV isolates have not always accounted for potential co-infections.

Purpose of the Study:

  • To compare the in vivo pathogenicity of two Marek's disease virus (MDV) serotype 1 isolates: RB1B and T. King (TK).
  • To assess the impact of these isolates on host factors including body and organ weights, mortality, and lesion development.
  • To identify potential confounding factors in MDV pathogenicity studies.

Main Methods:

  • In vivo comparison of RB1B and T. King (TK) serotype 1 MDV isolates in chickens.

Related Experiment Videos

  • Monitoring of body and organ weights, mortality rates, and gross pathological lesions.
  • Subsequent analysis of the TK inoculum for the presence of other viral agents.

    • Main Results:

    • The TK isolate demonstrated more efficient early infection establishment compared to the RB1B isolate.
    • Greater damage to the bursa of Fabricius and thymus was observed with the TK inoculum.
    • Post-study analysis revealed chicken infectious anemia virus (CIAV) contamination in the TK inoculum.

    Conclusions:

    • The observed pathogenicity profile of the TK isolate was influenced by co-infection with CIAV.
    • Pathogenicity comparisons of MDV isolates require careful consideration of potential viral contamination.
    • Future studies should ensure the purity of viral stocks for accurate pathogenicity assessments.