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Updated: Oct 6, 2026

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis
Published on: May 18, 2016
Chemokines are produced in the brain early during the course of experimental African trypanosomiasis
A Sharafeldin1, R Eltayeb, M Pashenkov
1Division of Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden. ahmed.sharafeldin@impi.ki.se
Abstract:
African trypanosomiasis is characterized by progressive central nervous system (CNS) involvement. Using single and double immunohistochemistry, we evaluated the induction of alpha- and beta-chemokines in brains of Sprague-Dawley rats infected with Trypanosoma brucei brucei (T. b. brucei) and identified their cellular source. The results showed high production of MIP-2, RANTES and MIP-1alpha and to a lower extend MCP-1 in infected animals compared to controls. MIP-2, RANTES and MIP-1alpha were produced early by astrocytes and microglia and later by macrophages and T-cells. These findings suggest that chemokines may contribute to the immunopathogenesis that occurs in the CNS early during infections.
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