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Massive ibuprofen ingestion with survival.

S A Seifert1, A C Bronstein, T McGuire

  • 1Rocky Mountain Poison and Drug Center, Denver, Colorado, USA. sseifert@pol.net

Journal of Toxicology. Clinical Toxicology
|March 4, 2000
PubMed
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A massive ibuprofen overdose in an adolescent led to coma and metabolic acidosis but was successfully treated with supportive care, demonstrating survival without lasting effects from the nonsteroidal anti-inflammatory drug (NSAID) ingestion.

Area of Science:

  • Toxicology
  • Adolescent Medicine
  • Emergency Medicine

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are common analgesics.
  • Intentional or accidental overdoses can occur, posing significant health risks.

Observation:

  • A case of a massive 100 g ibuprofen ingestion in an adolescent is presented.
  • The patient exhibited symptoms including coma, metabolic acidosis, and mild thrombocytopenia.

Findings:

  • Despite the large ibuprofen dose, the patient showed rapid improvement with supportive medical care.
  • Crucially, normal renal function was maintained, and no gastrointestinal bleeding was observed.

Implications:

  • Massive ibuprofen ingestion can present with varied toxicological effects.

Related Experiment Videos

  • Prompt supportive care is critical for survival and preventing long-term sequelae in such overdose cases.