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Is absolute noninvasive temperature measurement by the Pr[MOE-DO3A] complex feasible
M Hentschel1, M Findeisen, W Schmidt
1Strahlenklinik und Poliklinik, Charité, Medizinische Fakultät der Humboldt Universität, Berlin, Germany. michael.hentschel@charite.de
Magma (New York, N.Y.)
|March 4, 2000
Summary
The praseodymium complex Pr[MOE-DO3A] enables accurate, non-invasive temperature measurements using 1H-NMR spectroscopy. This method offers high precision, comparable to fiber-optic probes, for various media like water and plasma.
Area of Science:
- Nuclear Magnetic Resonance (NMR) Spectroscopy
- Medical Imaging and Sensing
- Chemical Thermodynamics
Background:
- The praseodymium complex of 10-(2-methoxyethyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetate (Pr[MOE-DO3A]) has shown feasibility for non-invasive temperature measurements.
- Previous studies demonstrated its utility in in vivo spectroscopy and spectroscopic imaging with varying temporal resolutions.
- Current methods necessitate specific calibration curves for experimental conditions, limiting broader application.
Purpose of the Study:
- To evaluate the Pr[MOE-DO3A] probe with 1H-NMR spectroscopy for accurate, non-invasive absolute temperature measurements.
- To determine if the probe allows for precise temperature determination without the need for medium-specific calibration curves.
Main Methods:
- Utilized 1H-NMR spectroscopy to measure temperature-dependent chemical shift differences.
- Derived calibration curves for the Pr[MOE-DO3A] complex in two distinct media: distilled water and human plasma.
- Analyzed the temperature dependence of the chemical shift difference (F) between the OCH3 group of Pr[MOE-DO3A] and water.
Main Results:
- Calibration curves in water and plasma showed a slight, yet significant, dependence on the surrounding medium.
- The derived equations were F = -(27.53 ± 0.04) + (0.125 ± 0.001) x T for water and F = -(27.61 ± 0.02) + (0.129 ± 0.001) x T for plasma.
- Temperature errors were estimated at ±0.18°C for water and ±0.14°C for plasma, demonstrating high accuracy comparable to fiber-optic probes.
Conclusions:
- The Pr[MOE-DO3A] probe combined with 1H-NMR spectroscopy is feasible for absolute temperature measurements with high accuracy (up to ±0.2°C).
- Despite minor medium-dependent variations in calibration curves, the differences are negligible under practical conditions.
- This method offers a promising non-invasive approach for accurate temperature monitoring in diverse biological and chemical environments.