Childhood sexual abuse and preterm labor in adulthood: an endocrinological hypothesis

Anecdotal reports link adverse pregnancy outcomes, such as preterm delivery, to women with histories of childhood sexual abuse. Although little research has been conducted on this subject, we provide an overview of known health effects of violence against women and posit a biological explanation for adverse pregnancy outcomes among this population. Specifically, we hypothesize that early traumatic experiences of childhood sexual abuse may activate corticotropin releasing hormone (CRH) gene expression in the brain, and a vulnerability to elevated CRH gene expression in the placenta. Those traumatized by early abuse may be more susceptible to stress vís a vís CRH dysregulation during a major psychosocial stressor, such as pregnancy. Elevated CRH has been associated with preterm labor.